Time‐course manganese chloride biodistribution and manganese‐induced <scp>MRI</scp> contrast in mouse organs
The subcutaneous injection route provided substantial T<sub>1</sub> contrast enhancement in all tissues investigated, without toxicity at the maximum dose of 0.4 mmol/kg tested. However, the injection dose and optimal postinjection imaging interval must be tailored to the organ of interest.
Authors
- Kyle D. W. Vollett (ORCID: https://orcid.org/0000-0001-6057-0935)
- Hai‐Ling Margaret Cheng (ORCID: https://orcid.org/0000-0002-0733-9512)
- Keyu Zhuang (ORCID: https://orcid.org/0009-0003-6282-1357)
- Yan Chang
- Minbo Hou
Institutions
- University of Toronto (CA)
- Ted Rogers Centre for Heart Research (CA)
- Shanghai Institute of Pharmaceutical Industry (CN)
Publication Details
- Journal
- Magnetic Resonance in Medicine
- Published
- 2025-04-06
- DOI
- https://doi.org/10.1002/mrm.30522
- Citations
- 1
- Primary Topic
- Trace Elements in Health
- Type
- article
- Field-Weighted Citation Impact
- 1.12
Funders
- Canada Foundation for Innovation
- Natural Sciences and Engineering Research Council of Canada