Association between A body shape index and bone mineral density in middle-aged and elderly adults: a retrospective analysis of NHANES 2005–2018
ABSI's robust inverse associations with femoral BMD (β = -0.27 to -0.31), persisting across nonlinear threshold analyses, establish it as a novel biomarker of central adiposity-related skeletal fragility. Unlike conventional indices reflecting mechanical loading benefits (BMI β = 0.008-0.012; WC β = 0.003-0.005; WHtR β = 0.41-0.69), ABSI specifically captures visceral fat-driven metabolic disorder-a critical pathway for osteoporosis risk stratification in normal-weight and obese populations.
Authors
- Minshan Feng (ORCID: https://orcid.org/0000-0003-1130-3085)
- Xiaokuan Qin (ORCID: https://orcid.org/0000-0002-6993-1247)
- Bowen Yang (ORCID: https://orcid.org/0000-0002-3557-6814)
- Kai Sing Sun (ORCID: https://orcid.org/0000-0003-0631-9699)
- Weili Duan (ORCID: https://orcid.org/0000-0002-1503-8066)
- Z. Wang
- Bo Xu (ORCID: https://orcid.org/0000-0002-1165-7302)
- Xin Chen (ORCID: https://orcid.org/0000-0002-3685-0854)
- Liguo Zhu (ORCID: https://orcid.org/0000-0003-1748-418X)
- He Yin (ORCID: https://orcid.org/0000-0003-2055-3270)
- Guo-Liang Ma
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Wangjing Hospital of China Academy of Chinese Medical Sciences (CN)
- Beijing Hospital of Traditional Chinese Medicine (CN)
- Anyang Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-04-07
- DOI
- https://doi.org/10.3389/fendo.2025.1506841
- Citations
- 2
- Primary Topic
- Bone health and osteoporosis research
- Type
- article
- Field-Weighted Citation Impact
- 3.44