Uric acid-induced cardiomyocytic polyamines’ insufficience: a potential mechanism mediates cardiomyocytic injury
Uric acid disrupts polyamine homeostasis, leading to mitochondrial dysfunction and cardiomyocyte damage. Exogenous polyamine supplementation demonstrates therapeutic potential by preserving mitochondrial integrity. These findings unveil a potential mechanism underlying uric acid-induced cardiac injury and propose polyamine replenishment as a viable intervention strategy for hyperuricemia-related cardiovascular complications.
Authors
- Qiang Zheng (ORCID: https://orcid.org/0000-0002-2247-718X)
- Wei‐Ting Lin (ORCID: https://orcid.org/0000-0003-4792-4457)
- Ting Wu (ORCID: https://orcid.org/0000-0002-2954-1279)
- Jianxin Pang (ORCID: https://orcid.org/0000-0002-0053-2723)
- Cuiting Lin
- Yang Yang (ORCID: https://orcid.org/0000-0002-1163-2359)
- Lin Chen (ORCID: https://orcid.org/0000-0003-4798-6199)
- Hou‐Yong Yu (ORCID: https://orcid.org/0000-0002-6543-5924)
Institutions
- Longgang Central Hospital (CN)
- Shenzhen Sixth People's Hospital (CN)
- Foshan Maternity and Child Health Care Hospital (CN)
- ShenZhen People’s Hospital (CN)
- Southern Medical University Shenzhen Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-04-07
- DOI
- https://doi.org/10.3389/fendo.2025.1504614
- Citations
- 2
- Primary Topic
- Polyamine Metabolism and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China
- Southern Medical University