Risk of adverse outcomes associated with mirtazapine compared to sertraline use among older people living in long-term care facilities
Compared to sertraline, mirtazapine use is associated with a higher risk of mortality and, after 90 days of use, a lower risk of falls and fractures. This risk of harm should be balanced with limited evidence for effectiveness when considering antidepressant therapy in LTCFs.
Authors
- Megan Corlis (ORCID: https://orcid.org/0000-0001-8432-3912)
- Debra Rowett (ORCID: https://orcid.org/0000-0002-8977-0401)
- Gillian E. Caughey (ORCID: https://orcid.org/0000-0003-1192-4121)
- Catherine Lang (ORCID: https://orcid.org/0000-0003-4828-5749)
- Janet K. Sluggett (ORCID: https://orcid.org/0000-0002-9059-5209)
- Georgina A. Hughes (ORCID: https://orcid.org/0000-0001-9938-1912)
- Maria C. Inacio (ORCID: https://orcid.org/0000-0001-8261-2665)
- Tracy Air (ORCID: https://orcid.org/0000-0002-4834-4238)
Institutions
- Flinders University (AU)
- University of South Australia (AU)
- Women's and Children's Health Network (AU)
- South Australian Health and Medical Research Institute (AU)
- Australian Federation of University Women – South Australia (AU)
Publication Details
- Journal
- Age and Ageing
- Published
- 2025-03-28
- DOI
- https://doi.org/10.1093/ageing/afaf074
- Citations
- 3
- Primary Topic
- Geriatric Care and Nursing Homes
- Type
- article
- Field-Weighted Citation Impact
- 8.45
Funders
- South Australian Health and Medical Research Institute
- Government of South Australia
- Australian Government
- Flinders University
- NSW Ministry of Health
- Department for Innovation and Skills, Government of South Australia