Gut microbiome in patients with early-stage and late-stage endometriosis
The gut microbial community structure in early-stage endometriosis patients significantly differs from that in late-stage cases, with late-stage patients experiencing dysmenorrhea displaying particularly distinct gut profiles. Predicted functional analysis indicated suppressed steroid biosynthesis pathways in the gut of late-stage endometriosis patients. In conclusion, it is plausible that the multiple effects of steroids on the lower gastrointestinal tract may involve microbiota alterations, suggesting the need for further investigations.
Authors
- Sixia Huang
- Zhaoxia Cai (ORCID: https://orcid.org/0000-0002-8441-6446)
- Yuzhen Cao (ORCID: https://orcid.org/0000-0002-1975-2056)
- Yuying Chen (ORCID: https://orcid.org/0009-0003-2770-6337)
- Song Ma
- Ying Ma (ORCID: https://orcid.org/0000-0003-1856-101X)
- Ziwei Zhou (ORCID: https://orcid.org/0009-0004-2592-8283)
Institutions
- Guangdong Medical College (CN)
- Guangzhou Liwan District Traditional Chinese Medicine Hospital (CN)
- Zhujiang Hospital (CN)
- Affiliated Hospital of Guangdong Medical College Hospital (CN)
Publication Details
- Journal
- BMC Women s Health
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1186/s12905-025-03689-0
- Citations
- 5
- Primary Topic
- Endometriosis Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 8.49
Funders
- Southern Medical University
- Basic and Applied Basic Research Foundation of Guangdong Province