Gut microbiota contributes to protection against porcine deltacoronavirus infection in piglets by modulating intestinal barrier and microbiome
PDCoV infection altered the structure and composition of the gut microbiota in neonatal pigs. FMT treatment mitigated the clinical signs of PDCoV infection in the piglets by modulating the gut microbiota composition and intestinal barrier, downregulating the inflammatory response. The preventive effect of FMT provides novel targets for the development of therapeutics against enteropathogenic coronaviruses. Video Abstract.
Authors
- Xianhua Wan
- Shi-Jie Ma
- Lulu Si (ORCID: https://orcid.org/0000-0002-1722-6271)
- Xiangli Shu
- Zhanyong Wei (ORCID: https://orcid.org/0000-0001-8705-6426)
- Haiyan Li (ORCID: https://orcid.org/0000-0002-5541-3035)
- Hui Hu (ORCID: https://orcid.org/0000-0003-4514-5409)
- Yunfei Zhang (ORCID: https://orcid.org/0000-0002-4959-4167)
- Xiaohui Jin (ORCID: https://orcid.org/0009-0000-6536-7813)
- C J Qiu (ORCID: https://orcid.org/0009-0002-8373-6453)
Institutions
- Henan Agricultural University (CN)
Publication Details
- Journal
- Microbiome
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1186/s40168-025-02092-z
- Citations
- 11
- Primary Topic
- Animal Virus Infections Studies
- Type
- article
- Field-Weighted Citation Impact
- 13.13
Funders
- National Natural Science Foundation of China
- Henan Agricultural University