Guiqi Huoxue capsule alleviates cervical spondylosis in rats: Insights from 16S rRNA sequencing, lipidomics, and network pharmacology
This study elucidated the role of GQHX in alleviating CS and highlighted the mechanisms involved, particularly the regulation of gut microbiota and lipid metabolism, as well as the AGE-RAGE, MAPK, and HIF-1 signaling pathways.
Authors
- Dejun Niu
- Chenghong Sun (ORCID: https://orcid.org/0000-0002-7579-5472)
- Hongguang Tang
- Deyu Cui
- Jinyang Shen (ORCID: https://orcid.org/0000-0002-0469-181X)
- Wenting Ni
- Kun Wang (ORCID: https://orcid.org/0000-0001-9681-1593)
- Yue Zhou (ORCID: https://orcid.org/0000-0003-1794-9071)
- Shirong Li (ORCID: https://orcid.org/0000-0003-0227-901X)
- Mengmeng Shen (ORCID: https://orcid.org/0000-0003-2631-5126)
- Zhen Zeng (ORCID: https://orcid.org/0000-0002-4508-8515)
- Fanqiang Meng (ORCID: https://orcid.org/0000-0003-2200-1859)
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Lianyungang Oriental Hospital (CN)
- Luye Pharma (China) (CN)
- Ocean University of China (CN)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2025-04-06
- DOI
- https://doi.org/10.1016/j.jep.2025.119752
- Primary Topic
- Healthcare and Venom Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00