Cytokeratin 17 activates AKT signaling to induce epithelial-mesenchymal transition and promote bladder cancer progression
We found that high expression of CK17 promoted the proliferation, migration and invasion of bladder cancer cells and induced EMT through AKT-Ser473 phosphorylation. These findings suggest that CK17 is significantly associated with malignant progression and poor prognosis of bladder cancer patients, and it may become a new biological target for bladder cancer treatment.
Authors
- Shun Zhang (ORCID: https://orcid.org/0000-0002-7949-4191)
- Mingkai Liu (ORCID: https://orcid.org/0000-0001-9060-848X)
- Yuemian Liang
- Pei Zhang (ORCID: https://orcid.org/0000-0002-3297-899X)
- Jialin Liu (ORCID: https://orcid.org/0000-0002-9450-0772)
- Zhenyu Cui (ORCID: https://orcid.org/0000-0002-7548-3866)
- Yanan Wang (ORCID: https://orcid.org/0009-0007-2744-7733)
- Chunyan Bu
- Cuijuan Lu
- Qianhe Zu
Institutions
- Hebei Agricultural University (CN)
- Affiliated Hospital of Hebei University (CN)
- Hebei University (CN)
Publication Details
- Journal
- BMC Urology
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1186/s12894-025-01760-4
- Citations
- 3
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 6.02