Clinical-genomic characteristics of homologous recombination deficiency (HRD) in breast cancer: application model for practice
BRCA mutation status did not fully reflect HRD status. Patients with a negative HER2 status and high Ki- 67 index are more likely to exhibit positive results when undergoing HRD genetic testing. The ER, PR, HER- 2 status, Ki- 67 index, molecular typing, and histological grading may have a strong influence on the HRD status.
Authors
- Nan Ma (ORCID: https://orcid.org/0000-0002-8518-5627)
- Yu Ren (ORCID: https://orcid.org/0000-0003-2928-138X)
- Juan Du (ORCID: https://orcid.org/0000-0001-8190-3524)
- Yudong Zhou (ORCID: https://orcid.org/0000-0002-6364-3869)
- Jianing Zhang
- Jiaqi Zhang (ORCID: https://orcid.org/0000-0002-3143-5651)
- Xi Liu (ORCID: https://orcid.org/0000-0002-6318-7509)
- Danni Li (ORCID: https://orcid.org/0000-0002-2293-7473)
- Bin Wang (ORCID: https://orcid.org/0000-0002-2662-1986)
- Yalong Wang (ORCID: https://orcid.org/0000-0002-9557-9101)
- Lizhe Zhu (ORCID: https://orcid.org/0000-0002-5507-6323)
- Chaorui Duan
Institutions
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- University Medical Centre Mannheim (DE)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1186/s40001-025-02520-8
- Citations
- 1
- Primary Topic
- PARP inhibition in cancer therapy
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- National Natural Science Foundation of China
- Key Research and Development Projects of Shaanxi Province