Wolfram syndrome 2 gene (CISD2) deficiency disrupts Ca2+-mediated insulin secretion in β-cells
These findings provide mechanistic insights and form a basis for developing therapeutics for the effective treatment of diabetes in WFS2 patients.
Authors
- Chi‐Chang Juan (ORCID: https://orcid.org/0000-0001-5935-6675)
- Shao-Yu Hsiung
- Zhao‐Qing Shen (ORCID: https://orcid.org/0000-0001-9126-0219)
- Wen‐Tai Chiu (ORCID: https://orcid.org/0000-0003-0310-0675)
- Tsai‐Yu Tzeng (ORCID: https://orcid.org/0000-0001-7334-6270)
- Ting‐Fen Tsai (ORCID: https://orcid.org/0000-0003-3239-4430)
- Tsai-Wen Teng
- Yu‐Chen Chen (ORCID: https://orcid.org/0000-0002-8539-7224)
- Li‐Hsien Chen (ORCID: https://orcid.org/0000-0002-4321-1882)
- Chien-Yi Tung
- Cheng-Heng Kao
Institutions
- National Yang Ming Chiao Tung University (TW)
- Chang Gung University (TW)
- National Cheng Kung University Hospital (TW)
- National Cheng Kung University (TW)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-04-06
- DOI
- https://doi.org/10.1016/j.molmet.2025.102140
- Citations
- 1
- Primary Topic
- Endoplasmic Reticulum Stress and Disease
- Type
- article
- Field-Weighted Citation Impact
- 1.15
Funders
- National Health Research Institutes