Mendelian randomization analysis of blood metabolites and immune cell mediators in relation to GVHD and relapse
Our findings provide novel insights into the metabolic mechanisms underlying GVHD and relapse after allo-HSCT. Identified metabolites, particularly pyridoxate, may serve as potential therapeutic targets for GVHD prevention and management.
Authors
- Xinghao Yu (ORCID: https://orcid.org/0000-0002-0589-0386)
- Ying Shen (ORCID: https://orcid.org/0000-0003-0656-7377)
- Dandan Lin (ORCID: https://orcid.org/0000-0003-3843-6945)
- Jia Chen (ORCID: https://orcid.org/0000-0003-3691-4085)
- Pengfei Li (ORCID: https://orcid.org/0000-0003-4464-9541)
- Yang Xu (ORCID: https://orcid.org/0000-0002-5398-087X)
- Yi Fan (ORCID: https://orcid.org/0000-0002-5989-9140)
- Yi Jin (ORCID: https://orcid.org/0009-0004-8391-3178)
- Yiyin Chen (ORCID: https://orcid.org/0000-0003-0629-2174)
- Huimin Lu
- Chang Hou (ORCID: https://orcid.org/0000-0003-4883-068X)
- Lei Lei (ORCID: https://orcid.org/0009-0000-3826-9169)
- Depei Wu (ORCID: https://orcid.org/0000-0002-0050-9830)
Institutions
- Jiangsu University (CN)
- Soochow University (CN)
- First Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-04-06
- DOI
- https://doi.org/10.1186/s12916-025-04026-w
- Citations
- 1
- Primary Topic
- Diabetes and associated disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- Fred Hutchinson Cancer Research Center
- Jiangsu Commission of Health
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province
- Soochow University
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- National Key Research and Development Program of China
- Science and Technology Program of Suzhou