Dynamic substrate topographies drive actin- and vimentin-mediated nuclear mechanoprotection events in human fibroblasts
Together, these data reveal that fibroblasts actively protect their nuclei in the presence of dynamic topographical changes through cytoskeleton-mediated mechanisms. Broadly, these results stress the importance of gaining a deeper fundamental understanding of the cellular mechanoresponse under dynamically changing conditions.
Authors
- Nicholas A. Kurniawan (ORCID: https://orcid.org/0000-0003-0473-0222)
- Carlijn V. C. Bouten (ORCID: https://orcid.org/0000-0003-1035-5094)
- Leila S. Coelho‐Rato (ORCID: https://orcid.org/0000-0002-1584-5415)
- Cecilia Sahlgren (ORCID: https://orcid.org/0000-0003-3350-4937)
- Maaike Bril
- Jules N Boesveld
Institutions
- Åbo Akademi University (FI)
- Eindhoven University of Technology (NL)
Publication Details
- Journal
- BMC Biology
- Published
- 2025-04-06
- DOI
- https://doi.org/10.1186/s12915-025-02199-7
- Citations
- 3
- Primary Topic
- Cellular Mechanics and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 3.45
Funders
- European Commission
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Turun Yliopisto
- Åbo Akademi
- European Research Council