Effect of intra-articular corticosteroid injections for knee osteoarthritis on the rates of subsequent knee replacement and post-operative outcomes: a national cohort study of England
Findings from our main analysis suggest that short-term pain reduction following IACI for knee osteoarthritis may translate to lower rates of knee replacement over 5 years follow-up, although contradictory associations were observed in secondary analyses which likely reflected residual confounding by indication. Reassuringly, IACI use before knee replacement was not associated with post-operative adverse outcomes.
Authors
- Samuel Hawley (ORCID: https://orcid.org/0000-0002-7034-6168)
- Albert Prats‐Uribe (ORCID: https://orcid.org/0000-0003-1202-9153)
- Antonella Delmestri
- Gulraj S. Matharu (ORCID: https://orcid.org/0000-0003-1098-9230)
- Andrew Judge (ORCID: https://orcid.org/0000-0003-3015-0432)
- Michael Richard Whitehouse (ORCID: https://orcid.org/0000-0003-2436-9024)
- Daniel Prieto-Alhambra
Institutions
- University Hospitals Bristol NHS Foundation Trust (GB)
- Nuffield Orthopaedic Centre (GB)
- University of Bristol (GB)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-04-06
- DOI
- https://doi.org/10.1186/s12916-025-04000-6
- Citations
- 1
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.67
Funders
- National Institute for Health and Care Research
- Department of Health and Social Care
- Medical Research Council
- Health Technology Assessment Programme