Double-negative T cells in combination with ursodeoxycholic acid ameliorates immune-mediated cholangitis in mice
A single transfer of DNT ameliorated PBC in mice, while combination therapy of DNT with oral UDCA displayed a better efficacy, with stronger inhibition of hepatic T and B cells. This study highlights the potential application of DNT-based combination therapy for PBC, especially for UDCA non-responders.
Authors
- Jidong Jia (ORCID: https://orcid.org/0000-0002-4673-8890)
- Xinyan Zhao (ORCID: https://orcid.org/0000-0002-8016-4368)
- Guangyong Sun (ORCID: https://orcid.org/0009-0000-1379-5752)
- Chunpan Zhang (ORCID: https://orcid.org/0000-0002-4750-2564)
- Shimeng Zheng
- Dong Zhang (ORCID: https://orcid.org/0000-0002-3404-5173)
- Xiyu Wang (ORCID: https://orcid.org/0009-0002-7558-6504)
- Hua Jin (ORCID: https://orcid.org/0000-0001-8120-3149)
- Yunxiong Wei (ORCID: https://orcid.org/0000-0003-0088-7775)
Institutions
- Capital Medical University (CN)
- Beijing Chao-Yang Hospital, Capital Medical University (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Beijing Friendship Hospital (CN)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-04-06
- DOI
- https://doi.org/10.1186/s12916-025-04043-9
- Primary Topic
- Liver Diseases and Immunity
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Beijing Municipality
- Beijing Municipal Administration of Hospitals