Molecular hyperselection for optimal choice of first-line targeted therapy independent of primary tumor sidedness: An exploratory analysis of the randomized FIRE-3 study performed in RAS wild-type metastatic colorectal cancer
Molecular hyperselection facilitated by next generation sequencing could replace primary tumor sidedness as a tool of decision making for optimal choice of targeted therapy in first-line treatment of RAS wild-type mCRC.
Authors
- Lena Weiss (ORCID: https://orcid.org/0000-0002-8101-3529)
- Arndt Stahler (ORCID: https://orcid.org/0000-0003-1041-0137)
- Alexander Kiani (ORCID: https://orcid.org/0000-0002-2494-4087)
- Sebastian Stintzing (ORCID: https://orcid.org/0000-0002-3297-5801)
- Thomas Decker (ORCID: https://orcid.org/0000-0003-3814-8775)
- Julian Walter Holch (ORCID: https://orcid.org/0000-0002-4755-0179)
- Andreas Werner Jung (ORCID: https://orcid.org/0000-0003-3068-3212)
- Ursula Vehling‐Kaiser
- Dominik Paul Modest (ORCID: https://orcid.org/0000-0002-6853-0599)
- Annabel Helga Sophie Alig (ORCID: https://orcid.org/0000-0002-3922-3450)
- Kathrin Heinrich (ORCID: https://orcid.org/0000-0003-3580-2313)
- Christoph Kahl (ORCID: https://orcid.org/0000-0002-9370-5928)
- Tobias Heintges
- Ludwig Fischer von Weikersthal (ORCID: https://orcid.org/0000-0002-9128-0807)
- C. Benedikt Westphalen
- G. Seipelt
- Christian Lerchenmüller
- Frank Kullmann
- Salah-Edin Al-Batran
- Volker Heinemann
Institutions
- Goethe University Frankfurt (DE)
- University of Applied Sciences Landshut (DE)
- Bayreuth Medical Center (DE)
- LMU Klinikum (DE)
- Humboldt-Universität zu Berlin (DE)
- Klinikum Magdeburg (DE)
- Klinikum Weiden (DE)
- Institute of Clinical Cancer Research (DE)
- University Hospital Frankfurt (DE)
- Krankenhaus Nordwest (DE)
- University Hospital Magdeburg (DE)
- Praxis für Hämatologie und Onkologie (DE)
- Lukaskrankenhaus (DE)
- University of Rostock (DE)
- Freie Universität Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- European Journal of Cancer
- Published
- 2025-04-06
- DOI
- https://doi.org/10.1016/j.ejca.2025.115399
- Citations
- 5
- Primary Topic
- Colorectal Cancer Treatments and Studies
- Type
- article
- Field-Weighted Citation Impact
- 5.23