Nutraceuticals Targeting Cannabinoid Receptor 1 and Transient Receptor Potential Vanilloid 1 for Pain Relief: A Computational Screening Approach
Ginsenoside Rb1 and cyanidin 3-O-rutinoside exhibit high binding affinity, stability, and favorable pharmacokinetic properties, supporting their potential as non-opioid analgesic candidates. Their ability to modulate pain pathways in vitro and in vivo warrants further investigation.
Authors
- Hassan Mirzaei (ORCID: https://orcid.org/0000-0001-9407-1456)
- Tayyaba G. Hasan (ORCID: https://orcid.org/0000-0003-0871-6057)
- Mostafa Mohammadi (ORCID: https://orcid.org/0000-0002-7084-0182)
- Ali Jabbari
- Hamed A Flaifel
Institutions
- Golestan University (IR)
- Imam Khomeini Hospital (IR)
- Golestan University of Medical Sciences (IR)
- King Hamad University Hospital (BH)
Publication Details
- Journal
- Cureus
- Published
- 2025-04-06
- DOI
- https://doi.org/10.7759/cureus.81807
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Golestan University of Medical Sciences