Nasal transcriptome differences preceding recurrent wheezing in infancy
The nasal transcriptome in early infancy is associated with subsequent recurrent wheezes, indicating upregulation of immune cell chemotaxis, decreased epithelial barrier function, and altered cilium organization and mitochondrial function. Future studies are required to evaluate the use of nasal transcriptome in the early detection of infants at risk of recurrent wheeze and to generate new knowledge of antecedent pathways as targets for novel primary prevention strategies.
Authors
- Luba Sominsky (ORCID: https://orcid.org/0000-0002-0674-8824)
- Mimi L.K. Tang (ORCID: https://orcid.org/0000-0002-3839-5293)
- Fiona Collier (ORCID: https://orcid.org/0000-0002-5438-480X)
- Poshmaal Dhar (ORCID: https://orcid.org/0000-0002-2842-007X)
- Peter Vuillermin (ORCID: https://orcid.org/0000-0002-6580-0346)
- Peter D. Sly (ORCID: https://orcid.org/0000-0001-6305-2201)
- Martin O’Hely (ORCID: https://orcid.org/0000-0002-0212-1207)
- Toby Mansell (ORCID: https://orcid.org/0000-0002-1282-6331)
- Sarah Ashley (ORCID: https://orcid.org/0000-0001-9973-9742)
- David Burgner (ORCID: https://orcid.org/0000-0002-8304-4302)
- Anne‐Louise Ponsonby (ORCID: https://orcid.org/0000-0002-6581-3657)
- Richard Saffery (ORCID: https://orcid.org/0000-0002-9510-4181)
- Sarath Ranganathan (ORCID: https://orcid.org/0000-0002-6975-0307)
- Rachel L. Morgan (ORCID: https://orcid.org/0009-0009-1817-5523)
Institutions
- Barwon Health (AU)
- Royal Children's Hospital (AU)
- Deakin University (AU)
- The University of Queensland (AU)
Publication Details
- Journal
- Journal of Allergy and Clinical Immunology
- Published
- 2025-04-06
- DOI
- https://doi.org/10.1016/j.jaci.2025.03.021
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00