Effect of the vaginal live biotherapeutic LACTIN-V (Lactobacillus crispatus CTV-05) on vaginal microbiota and genital tract inflammation among women at high risk of HIV acquisition in South Africa: a phase 2, randomised, placebo-controlled trial
US National Institute of Child Health and Human Development and US National Institute of Allergy and Infectious Diseases.
Authors
- Ian Mbano (ORCID: https://orcid.org/0000-0002-2583-4760)
- Sinaye Ngcapu (ORCID: https://orcid.org/0000-0002-9625-8131)
- Craig R. Cohen (ORCID: https://orcid.org/0000-0001-8654-6634)
- Agnès Bergerat
- Anke Hemmerling (ORCID: https://orcid.org/0000-0002-6472-4804)
- Vanessa Pillay
- Nasreen Ismail (ORCID: https://orcid.org/0000-0001-7026-3605)
- Thumbi Ndung’u (ORCID: https://orcid.org/0000-0003-2962-3992)
- Joseph Elsherbini (ORCID: https://orcid.org/0000-0001-5995-2936)
- Jayajothi Moodley (ORCID: https://orcid.org/0000-0001-5550-9822)
- Lenine J. P. Liebenberg (ORCID: https://orcid.org/0000-0001-6768-8776)
- Vaneshree Govender
- Nondumiso Xulu
- Tess H. Brunner (ORCID: https://orcid.org/0000-0001-9315-791X)
- Caroline M. Mitchell (ORCID: https://orcid.org/0000-0001-9924-2349)
- Krista L. Dong (ORCID: https://orcid.org/0000-0002-2038-3518)
- Douglas S. Kwon (ORCID: https://orcid.org/0000-0001-8521-8735)
- Jiawu Xu (ORCID: https://orcid.org/0000-0002-0424-0736)
- Thomas Parks (ORCID: https://orcid.org/0000-0002-0251-0229)
- G Casillas
- Johnathan Shih
- Laurel A. Lagenaur
- Suuba Demby
- Musie Gebremichael
Institutions
- University of South Africa (ZA)
- University of California, San Francisco (US)
- Centre for the AIDS Programme of Research in South Africa (ZA)
- Ragon Institute of MGH, MIT and Harvard (US)
- Massachusetts General Hospital (US)
- Aurum Institute (ZA)
- Africa Health Research Institute (ZA)
- Osel (United States) (US)
- University of KwaZulu-Natal (ZA)
Publication Details
- Journal
- The Lancet Microbe
- Published
- 2025-04-06
- DOI
- https://doi.org/10.1016/j.lanmic.2024.101037
- Citations
- 20
- Primary Topic
- Reproductive tract infections research
- Type
- article
- Field-Weighted Citation Impact
- 23.66
Funders
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases
- National Institute of Allergy and Infectious Diseases
- National Institute of Child Health and Human Development