C3aR1 on β cells enhances β cell function and survival to maintain glucose homeostasis
These findings indicate that C3aR1 expression on β cells is necessary to maintain optimal β cell function and preserve β cell mass in T2D.
Authors
- Renan Pereira de Lima (ORCID: https://orcid.org/0000-0001-9653-7037)
- Ankit Gilani (ORCID: https://orcid.org/0000-0002-5100-0110)
- Isabella Y. Kong (ORCID: https://orcid.org/0000-0002-7480-4525)
- Ang Li (ORCID: https://orcid.org/0000-0003-0359-3510)
- James C. Lo (ORCID: https://orcid.org/0000-0003-0244-1670)
- Charles David Warren
- Alfonso Rubio‐Navarro (ORCID: https://orcid.org/0000-0001-5677-3123)
- Jacob B. Geri (ORCID: https://orcid.org/0000-0002-9215-5610)
Institutions
- Cornell University (US)
- Tri-Institutional PhD Program in Chemical Biology (US)
- Weill Cornell Medicine (US)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-04-06
- DOI
- https://doi.org/10.1016/j.molmet.2025.102134
- Citations
- 4
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 6.02
Funders
- American Cancer Society
- American Diabetes Association Research Foundation
- American Heart Association
- National Institute of Diabetes and Digestive and Kidney Diseases