THE EFFECT OF CURCUMIN ON CHANGES IN OXIDATIVE STRESS PARAMETERS IN ANIMAL MODEL OF RHEUMATOID ARTHRITIS: A PILOT STUDY
The aim of this study was to examine the antioxidant capacity of curcumin and whether it modulates RA-induced oxidative stress. Pro-oxidants from plasma and coronary venous effluent were determined spectrophotometrically. The concentration of nitrite was significantly lower in the curcumin treated group compared to the disease group (p < 0.05), while the concentrations of superoxide anion radical, hydrogen peroxide and lipid peroxidation index were lower in curcumin group, but without statistical significance between the groups. Curcumin has a beneficial antioxidant effect in the treatment of RA, but considering that this was a pilot study, additional investigations will be performed.
Authors
- Katarina Mihajlović (ORCID: https://orcid.org/0000-0002-3262-3275)
- Vladimir Jakovljević (ORCID: https://orcid.org/0000-0002-0071-8376)
- Božidar Pindović (ORCID: https://orcid.org/0009-0000-7603-5865)
- Zorka Stanić (ORCID: https://orcid.org/0000-0002-4813-9808)
- Tamara Nikolić Turnić (ORCID: https://orcid.org/0000-0002-9105-1350)
- Katarina S. Postolović (ORCID: https://orcid.org/0000-0002-6383-1659)
- Janoš Terzić (ORCID: https://orcid.org/0000-0003-3228-2076)
- Vladimir Živković (ORCID: https://orcid.org/0000-0001-9354-9876)
- Katarina Đorđević
Publication Details
- Published
- 2025-01-01
- DOI
- https://doi.org/10.46793/sbt30.74kdj
- Primary Topic
- Curcumin's Biomedical Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00