Membrane-associated ring–CH–type finger 2 protects against metabolic dysfunction-associated fatty liver disease by targeting fatty acid synthase
MARCH2 undergoes self-ubiquitination and plays an important role in maintaining the liver lipid homeostasis of MAFLD, and drug intervention in the MARCH2-FASN axis is a promising approach for treating systemic metabolic abnormalities in MAFLD.
Authors
- Yong Man
- Dehuan Liang
- Zhaolai Qi
- Shuang Ma (ORCID: https://orcid.org/0000-0002-6494-724X)
- Kefei Dou (ORCID: https://orcid.org/0000-0002-5464-2290)
- Dongsheng Ni (ORCID: https://orcid.org/0000-0001-5123-178X)
- Guoping Li (ORCID: https://orcid.org/0000-0002-0134-2593)
- Yuefeng Wang (ORCID: https://orcid.org/0000-0003-3960-5595)
- Xiyue Zhang (ORCID: https://orcid.org/0000-0003-0431-1773)
- Jingzhou Chen (ORCID: https://orcid.org/0000-0002-1642-003X)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Beijing Geriatric Hospital (CN)
- Fu Wai Hospital (CN)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-04-06
- DOI
- https://doi.org/10.1016/j.molmet.2025.102137
- Citations
- 1
- Primary Topic
- Peroxisome Proliferator-Activated Receptors
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- Chinese Academy of Medical Sciences
- Beijing Hospital