Deubiquitinating enzyme USP2 regulates brown adipose tissue thermogenesis via controlling EBF2 stabilization
Our data demonstrated the vital role of USP2 in regulating BAT activation and systemic energy homeostasis. Activation of USP2-EBF2 interaction could be a potential therapeutic strategy against obesity.
Authors
- Yafen Ye
- Jiemin Pan (ORCID: https://orcid.org/0000-0003-0474-1917)
- Ningning Bai (ORCID: https://orcid.org/0009-0009-0002-3230)
- Yuejie Xu (ORCID: https://orcid.org/0000-0002-0974-4132)
- Yingying Su (ORCID: https://orcid.org/0000-0002-0537-1551)
- Cheng Hu (ORCID: https://orcid.org/0000-0003-4314-2386)
- Ying Chen (ORCID: https://orcid.org/0000-0002-2688-8736)
- Rong Zhang (ORCID: https://orcid.org/0000-0002-6889-5571)
- Ying Yang (ORCID: https://orcid.org/0000-0001-8355-6642)
- Caizhi Liu
Institutions
- Shanghai Sixth People's Hospital (CN)
- Shanghai Clinical Research Center (CN)
- Jinzhou Medical University (CN)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-04-06
- DOI
- https://doi.org/10.1016/j.molmet.2025.102139
- Citations
- 1
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- National Natural Science Foundation of China