Development of a fully human glioblastoma-in-brain-spheroid model for accelerated translational research
This physiologically relevant human model system provides new opportunities for studying GBM biology and tumor-neuron interactions in a controlled environment. By bridging the gap between simplified in vitro systems and complex in vivo models, hGliCS represents a promising platform for therapeutic development and personalized medicine approaches in GBM treatment.
Authors
- Eric Zillich (ORCID: https://orcid.org/0000-0003-3704-7243)
- Frank Winkler (ORCID: https://orcid.org/0000-0003-4892-6104)
- Dirk C. Hoffmann (ORCID: https://orcid.org/0000-0003-1370-1933)
- Ammar Jabali (ORCID: https://orcid.org/0000-0002-2772-8531)
- David Hausmann (ORCID: https://orcid.org/0000-0002-0571-4710)
- Philipp Koch (ORCID: https://orcid.org/0000-0003-3713-8786)
- Sandra Horschitz (ORCID: https://orcid.org/0000-0001-9295-5493)
- Lea Zillich (ORCID: https://orcid.org/0000-0001-7457-374X)
- Wolfgang Wick (ORCID: https://orcid.org/0000-0002-6171-634X)
- Amit Kumar (ORCID: https://orcid.org/0000-0002-9214-994X)
- Daniel Domínguez Azorín (ORCID: https://orcid.org/0000-0002-0002-4307)
- Sophie Heuer (ORCID: https://orcid.org/0000-0002-3373-5295)
- Ling Hai
Institutions
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Central Institute of Mental Health (DE)
- National Center for Tumor Diseases (DE)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-04-06
- DOI
- https://doi.org/10.1016/j.jare.2025.03.055
- Citations
- 3
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.88