Lack of relationships between ketamine treatment and peripheral neurotrophic and inflammatory factors in a randomized controlled ketamine trial of major depressive disorder
Associations between ketamine treatment and peripheral neurotrophic/inflammatory factors were not detected in our RCT of 133 adults with TRD. The sole exception across exhaustive sensitivity analyses was that, in individuals with low BMI, increases in IL-1RA levels may be linked to worse immediate treatment response. Future research investigating CNS-specific NIF activity is needed to more definitively test the posited role of NIFs in ketamine's antidepressant mechanisms.
Authors
- Angela Griffo (ORCID: https://orcid.org/0000-0001-9904-0026)
- Shabnam Hossein (ORCID: https://orcid.org/0009-0009-0698-5369)
- Robert H. Howland (ORCID: https://orcid.org/0000-0002-6533-6010)
- Rebecca B. Price (ORCID: https://orcid.org/0000-0002-7590-4325)
- Anna L. Marsland (ORCID: https://orcid.org/0000-0001-8951-7513)
- Manivel Rengasamy (ORCID: https://orcid.org/0000-0002-1379-743X)
- Sanjay J. Mathew (ORCID: https://orcid.org/0000-0002-2715-6641)
- Tessa Kovats
- Crystal Spotts
- Meredith L. Wallace (ORCID: https://orcid.org/0000-0003-3951-890X)
- Benjamin Panny (ORCID: https://orcid.org/0000-0002-9571-9952)
- Zakary Hutchinson
Institutions
- University of Maryland, Baltimore (US)
- University of Maryland Medical Center (US)
- University of Pittsburgh (US)
- Baylor College of Medicine (US)
- UPMC Health System (US)
Publication Details
- Journal
- Brain Behavior and Immunity
- Published
- 2025-04-06
- DOI
- https://doi.org/10.1016/j.bbi.2025.04.006
- Citations
- 1
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.58
Funders
- University of Pittsburgh
- National Institutes of Health
- National Institute of Mental Health
- National Center for Advancing Translational Sciences