Evaluating the role of targeted silymarin loaded hyaluronic acid/protein nanoparticles in activating hepatic progenitor stem cells for liver regeneration after CCl4-induced liver damage
The novel point is that these results demonstrated that the targeted Silymarin NPs not only could efficiently alleviate CCl<sub>4</sub>-induced liver fibrosis more than using only free silymarin; by inhibiting the TGF-β/Smad-3 signaling pathway, but also could activate hepatic progenitor stem cells causing liver regeneration.
Authors
- Nemany A. N. Hanafy (ORCID: https://orcid.org/0000-0001-5861-6973)
- Maged El‐Kemary (ORCID: https://orcid.org/0000-0003-0679-1715)
- Rawan O El-Belkasy
Institutions
- Kafrelsheikh University (EG)
Publication Details
- Journal
- International Journal of Biological Macromolecules
- Published
- 2025-04-06
- DOI
- https://doi.org/10.1016/j.ijbiomac.2025.142837
- Citations
- 3
- Primary Topic
- Silymarin and Mushroom Poisoning
- Type
- article
- Field-Weighted Citation Impact
- 4.56