Genetically determined increase in apolipoprotein C-III (APOC3 gain-of-function) delays very low-density lipoprotein clearance in humans
APOC3 GOF carriers showed specific alterations in TRL metabolism (compared to matched non-carriers), namely slower lipolysis and delayed clearance of VLDL<sub>1</sub>-sized particles, but no difference in chylomicron metabolism. Our findings suggest that intervention to reduce apoC-III production can be modelled as a reduction in TRL, particularly VLDL particle levels, without deleterious effects on fat absorption or hepatic VLDL production.
Authors
- Sanni Söderlund
- Martin Adiels (ORCID: https://orcid.org/0000-0002-3667-589X)
- Niina Matikainen (ORCID: https://orcid.org/0000-0003-0041-1240)
- Elias Björnson (ORCID: https://orcid.org/0000-0002-0003-6463)
- Linda Andersson (ORCID: https://orcid.org/0000-0003-3230-5397)
- Marja‐Riitta Taskinen (ORCID: https://orcid.org/0000-0002-6229-3588)
- J. Boren
- C.J. Packard
Institutions
- University of Helsinki (FI)
- Helsinki University Hospital (FI)
- Sahlgrenska University Hospital (SE)
- University of Glasgow (GB)
- University of Gothenburg (SE)
Publication Details
- Journal
- Atherosclerosis
- Published
- 2025-04-06
- DOI
- https://doi.org/10.1016/j.atherosclerosis.2025.119166
- Citations
- 5
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 10.03