ctDNA can detect minimal residual disease in curative treated non-small cell lung cancer patients using a tumor agnostic approach
These findings suggest that post-treatment ctDNA, detected using a tumor-agnostic approach, is a reliable biomarker for predicting recurrence in NSCLC patients following curative treatment. However, the optimal timing for blood sampling to detect MRD appears to depend on the type of curative treatment received.
Authors
- M Bloch
- Oke Gerke (ORCID: https://orcid.org/0000-0001-6335-3303)
- Julie Marie Grüner
- Lars Borgbjerg Møller
- Karin Hjorthaug (ORCID: https://orcid.org/0000-0003-2045-6796)
- Svetlana Borissova
- Zaigham Saghir (ORCID: https://orcid.org/0000-0002-2693-8617)
- Christian Niels Meyer (ORCID: https://orcid.org/0000-0002-4784-4134)
- Peter Meldgaard (ORCID: https://orcid.org/0000-0002-5788-4463)
- Markus Nowak Lonsdale (ORCID: https://orcid.org/0000-0002-2916-5293)
- Charlotte Kristiansen (ORCID: https://orcid.org/0000-0002-8073-5781)
- Klaus Richter Larsen (ORCID: https://orcid.org/0000-0003-2519-3454)
- Peter Michael Gørtz (ORCID: https://orcid.org/0000-0002-9321-0781)
- Barbara Malene Fischer (ORCID: https://orcid.org/0000-0002-6065-3375)
- Anette Højsgaard
- Kristin Skougaard
- Ole Hilberg (ORCID: https://orcid.org/0000-0002-3075-3463)
- Signe Høyer Simonsen Schwaner
- Elisabeth Albrecht‐Beste
- Torben Riis Rasmussen (ORCID: https://orcid.org/0000-0002-7030-9260)
- Boe Sandahl Sørensen (ORCID: https://orcid.org/0000-0002-9472-8099)
- René Horsleben Petersen (ORCID: https://orcid.org/0000-0002-3586-1869)
- Jann Mortensen (ORCID: https://orcid.org/0000-0002-1399-8995)
- Martin Krakauer (ORCID: https://orcid.org/0000-0002-2191-1861)
- Malene Søby Christophersen
- Lise Saksø Mortensen (ORCID: https://orcid.org/0000-0002-4400-181X)
- Hanne Marie Nellemann
- Morten Dahl (ORCID: https://orcid.org/0000-0002-6686-312X)
- Tine McCulloch
- Joan Fledelius (ORCID: https://orcid.org/0000-0002-7825-7418)
- Lise Barlebo Ahlborn (ORCID: https://orcid.org/0000-0001-8021-7442)
- Paw Christian Holdgaard (ORCID: https://orcid.org/0000-0002-0122-0916)
- Kasper Guldbrandsen (ORCID: https://orcid.org/0000-0002-1921-0150)
- Christian Borbjerg Laursen (ORCID: https://orcid.org/0000-0001-6382-9906)
- Mette Poehl (ORCID: https://orcid.org/0000-0001-9266-8662)
- Anne Lerberg Nielsen (ORCID: https://orcid.org/0000-0002-6130-9736)
- Uffe Bødtger (ORCID: https://orcid.org/0000-0002-1231-9209)
- Lærke Rosenlund Nielsen (ORCID: https://orcid.org/0009-0009-5154-858X)
- Lotte Holm Land (ORCID: https://orcid.org/0000-0002-6208-7987)
- Søren Steen Nielsen
- Jeanette Haar Ehlers
Institutions
- University of Copenhagen (DK)
- University of Southern Denmark (DK)
- Aalborg University Hospital (DK)
- Frederiksberg Hospital (DK)
- Odense University Hospital (DK)
- Herlev Hospital (DK)
- Aarhus University Hospital (DK)
- Copenhagen University Hospital (DK)
- Gentofte Hospital (DK)
- Rigshospitalet (DK)
- Zealand University Hospital (DK)
- Regional Hospital Horsens (DK)
- Lillebaelt Hospital (DK)
- Aalborg University (DK)
Publication Details
- Journal
- Lung Cancer
- Published
- 2025-04-06
- DOI
- https://doi.org/10.1016/j.lungcan.2025.108528
- Citations
- 8
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 7.49
Funders
- Axel Muusfeldts Fond
- Novo Nordisk
- Helsefonden