Dipeptidyl peptidase 3 induces myocardial ischemia-reperfusion injury by mediating mitophagy and the intrinsic apoptotic pathway
The study demonstrated that DPP3 mediates mitophagy and apoptosis in MIRI through its interaction with Park7. These findings have important implications, suggesting that targeting DPP3 and its associated signaling pathways may serve as a potential therapeutic strategy, and that the downregulation of DPP3 can potentially alleviate MIRI.
Authors
- Chunyang Tian (ORCID: https://orcid.org/0000-0003-0466-8668)
- Yaofeng Xie
- Cheng Chang (ORCID: https://orcid.org/0000-0002-0361-2438)
- Xiao Wang (ORCID: https://orcid.org/0000-0003-3026-2477)
- Yuyao Yin
- Xiaodong Li (ORCID: https://orcid.org/0000-0002-5782-5172)
- Yilong Pan (ORCID: https://orcid.org/0000-0002-4970-7256)
- Hongjiao Du
Institutions
- China Medical University (CN)
Publication Details
- Journal
- European Journal of Pharmacology
- Published
- 2025-04-06
- DOI
- https://doi.org/10.1016/j.ejphar.2025.177592
- Citations
- 1
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 1.05