The Metabolomic Signature of Childhood Trauma
Childhood trauma was linked in a dose-response manner to a biological signature encompassing a wide array of metabolites. Dysregulations were observed in amino acid and fatty acid metabolism as well as hypothalamic-pituitary-adrenal axis function. Future studies should corroborate these findings and develop early-intervention strategies that target trauma-related biological mechanisms to prevent cardiometabolic and psychiatric diseases.
Authors
- Rick Jansen (ORCID: https://orcid.org/0000-0002-3333-6737)
- Erik J. Giltay (ORCID: https://orcid.org/0000-0001-8874-2292)
- Camille Souama (ORCID: https://orcid.org/0000-0001-5679-1436)
- Christiaan H. Vinkers (ORCID: https://orcid.org/0000-0003-3698-0744)
- Yuri Milaneschi (ORCID: https://orcid.org/0000-0002-3697-6617)
- Brenda W.J.H. Penninx (ORCID: https://orcid.org/0000-0001-7779-9672)
- Boadie W. Dunlop (ORCID: https://orcid.org/0000-0002-4653-0483)
- Femke Lamers (ORCID: https://orcid.org/0000-0003-4344-5766)
- Rima Kaddurah-Daouk
Institutions
- Emory University (US)
- Duke University (US)
- Leiden University Medical Center (NL)
- Amsterdam Neuroscience (NL)
- Duke University Hospital (US)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Biological Psychiatry
- Published
- 2025-04-06
- DOI
- https://doi.org/10.1016/j.biopsych.2025.03.018
- Citations
- 3
- Primary Topic
- Child Abuse and Trauma
- Type
- article
- Field-Weighted Citation Impact
- 6.92
Funders
- Amsterdam University Medical Centers
- European Commission
- Universiteit Leiden
- Rijksuniversiteit Groningen
- ZonMw
- Vrije Universiteit Amsterdam
- Ministerie van Onderwijs, Cultuur en Wetenschap
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- GGZ inGeest
- Rivierduinen
- GGZ Friesland
- GGZ Drenthe
- Leids Universitair Medisch Centrum
- Universitair Medisch Centrum Groningen
- Amsterdam Neuroscience
- Horizon 2020 Framework Programme
- National Institute on Aging
- National Institute of Mental Health