Application of Human Genetics to Prioritize Coagulation Cascade Protein Targets for Ischemic Stroke Prevention
These data highlight specific coagulation cascade components implicated in ischemic stroke pathogenesis, while identifying proteins with distinct roles in VTE. These findings may inform development of novel anticoagulants and optimize their use in targeted populations with stroke.
Authors
- Dipender Gill (ORCID: https://orcid.org/0000-0001-7312-7078)
- Ville Karhunen (ORCID: https://orcid.org/0000-0001-6064-1588)
- Anthony Kim (ORCID: https://orcid.org/0000-0002-8095-6517)
- Iyas Daghlas (ORCID: https://orcid.org/0000-0001-6924-0641)
Institutions
- University of California, San Francisco (US)
- MRC Biostatistics Unit (GB)
- Imperial College London (GB)
Publication Details
- Journal
- Stroke
- Published
- 2025-04-06
- DOI
- https://doi.org/10.1161/strokeaha.124.049808
- Citations
- 5
- Primary Topic
- Blood Coagulation and Thrombosis Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 8.85