PSA Absolute Value Versus PSA Response Rate: Which Is More Valuable for Estimating Survival Outcomes With ARPI Treatment for Metastatic Hormone‐Sensitive Prostate Cancer (mHSPC) in Real‐World Analyses?

Both the absolute value of PSA and the PSA response rate at 3 months after the initiation of ARPI can estimate survival outcomes. However, the PSA response rate is a more valuable surrogate marker for assessing treatment efficacy than the absolute PSA value. This is because the baseline clinical factors differ significantly among cohorts categorized by absolute PSA values, allowing for better predictions of survival outcomes at the start of treatment. Findings of this study could aid in decision-making following the initiation of doublet ARPI therapy within a short timeframe. Further studies are needed to validate our results.

Authors

Taro Igarashi (ORCID: https://orcid.org/0000-0002-5624-7614)
Keiichiro Miyajima (ORCID: https://orcid.org/0000-0002-7799-669X)
Naoki Otsuka
Fumihiko Urabe (ORCID: https://orcid.org/0000-0002-2599-8183)
Kosuke Iwatani (ORCID: https://orcid.org/0000-0001-5428-852X)
Wataru Fukuokaya (ORCID: https://orcid.org/0000-0003-1044-912X)
Jun Miki (ORCID: https://orcid.org/0000-0002-4638-8640)
Tatsuya Shimomura (ORCID: https://orcid.org/0009-0008-5840-1284)
Shunsuke Tsuzuki
Masaya Murakami (ORCID: https://orcid.org/0000-0002-1268-6615)
Takafumi Yanagisawa (ORCID: https://orcid.org/0000-0002-7410-0712)
Kojiro Tashiro
Sotaro Kayano (ORCID: https://orcid.org/0009-0001-0895-1551)
Yu Imai (ORCID: https://orcid.org/0000-0003-0971-4205)
Hidetsugu Takahashi
Takahiro Kimura
Kentaro Yoshihara (ORCID: https://orcid.org/0009-0008-7057-9712)
Hiroki Yamada
Katsuki Muramoto
Kota Katsumi
Keiichiro Mori

Institutions

Jikei University School of Medicine (JP)

Publication Details

Journal: The Prostate
Published: 2025-04-06
DOI: https://doi.org/10.1002/pros.24885
Citations: 3
Primary Topic: Prostate Cancer Treatment and Research
Type: article
Field-Weighted Citation Impact: 4.56

PSA Absolute Value Versus PSA Response Rate: Which Is More Valuable for Estimating Survival Outcomes With ARPI Treatment for Metastatic Hormone‐Sensitive Prostate Cancer (mHSPC) in Real‐World Analyses?

Taro Igarashi, Keiichiro Miyajima, Naoki Otsuka, Fumihiko Urabe, Kosuke Iwatani, Wataru Fukuokaya, Jun Miki, Tatsuya Shimomura, Shunsuke Tsuzuki, Masaya Murakami, Takafumi Yanagisawa, Kojiro Tashiro, Sotaro Kayano, Yu Imai, Hidetsugu Takahashi, Takahiro Kimura, Kentaro Yoshihara, Hiroki Yamada, Katsuki Muramoto, Kota Katsumi, Keiichiro Mori

April 6, 2025article en

3 citations

PSA Absolute Value Versus PSA Response Rate: Which Is More Valuable for Estimating Survival Outcomes With ARPI Treatment for Metastatic Hormone‐Sensitive Prostate Cancer (mHSPC) in Real‐World Analyses?

Authors

Institutions

Publication Details

PSA Absolute Value Versus PSA Response Rate: Which Is More Valuable for Estimating Survival Outcomes With ARPI Treatment for Metastatic Hormone‐Sensitive Prostate Cancer (mHSPC) in Real‐World Analyses?

PSA Absolute Value Versus PSA Response Rate: Which Is More Valuable for Estimating Survival Outcomes With ARPI Treatment for Metastatic Hormone‐Sensitive Prostate Cancer (mHSPC) in Real‐World Analyses?

Abstract

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