Dynamic O-GlcNAcylation and phosphorylation attract and expel proteins from RNA polymerase II to regulate mRNA maturation
We show that dynamic O-GlcNAcylation is a negative regulator of mRNA biosynthesis and propose that the addition and removal of the modification serve as quality control-steps to ascertain successful generation of mature mRNAs. Our work identifies unprecedented redundancy in the regulation of RNA Pol II, which increases resilience towards transcriptional stress, and also underscores the difficulty of targeting transcription to control cancer.
Authors
- Harri M. Itkonen (ORCID: https://orcid.org/0000-0002-5194-7064)
- Aishwarya Gondane (ORCID: https://orcid.org/0000-0002-7495-2472)
Institutions
- University of Helsinki (FI)
- Helsinki Institute of Physics (FI)
Publication Details
- Journal
- Journal of Biomedical Science
- Published
- 2025-04-04
- DOI
- https://doi.org/10.1186/s12929-025-01135-9
- Citations
- 4
- Primary Topic
- Glycosylation and Glycoproteins Research
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- Academy of Finland
- Magnus Ehrnroothin Säätiö
- China Scholarship Council
- Oskar Öflunds Stiftelse
- Sigrid Juséliuksen Säätiö
- K. Albin Johanssons Stiftelse
- Syöpäsäätiö
- Biocenter Finland
- Jenny ja Antti Wihurin Rahasto