Preoperative inflammatory pain exacerbates postoperative pain and neurocognitive impairment
Our study shows that preoperative inflammatory pain further aggravates postoperative pain and neurocognitive dysfunction in aged rats, and the mechanism may be related to neuroinflammation caused by α7nAChR-mediated CAP dysfunction and high release of HMGB1.
Authors
- Daofan Sun (ORCID: https://orcid.org/0000-0001-5564-950X)
- Rongjun Liu (ORCID: https://orcid.org/0000-0002-7822-5395)
- Qiusheng Wang (ORCID: https://orcid.org/0000-0002-3197-6327)
- Yiqin Ji (ORCID: https://orcid.org/0000-0001-7207-2626)
- Bo Lu (ORCID: https://orcid.org/0000-0003-1815-6778)
- Ruichun Wang (ORCID: https://orcid.org/0000-0001-9328-8450)
- Xiuzhong Xing
- Bo Meng (ORCID: https://orcid.org/0000-0003-4299-9310)
- Junping Chen (ORCID: https://orcid.org/0000-0002-6268-719X)
- Hui Yuan (ORCID: https://orcid.org/0000-0002-3794-5353)
- Qianyu Ming
Institutions
- Ningbo University (CN)
Publication Details
- Journal
- IBRO Neuroscience Reports
- Published
- 2025-04-06
- DOI
- https://doi.org/10.1016/j.ibneur.2025.03.010
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00