Relationship between Vitamin E Intake and Incident Cardiovascular Diseases

Introduction: Cardiovascular diseases are responsible for about one-third of deaths worldwide. Consequently, innovative strategies for the development and treatment of cardiovascular diseases are of great interest. Vitamin E is known for its unique and remarkable anti-oxidant and anti-inflammatory properties. The advantages of vitamin E in cardiovascular diseases have been investigated and the relationship between lower vitamin E levels and increased cardiovascular events supports this view. However, clinical trials reveal inconsistent and disappointing results in reducing cardiovascular events with vitamin E supplementation. The analysis of studies shows that in addition to the amount, duration of consumption, the type of vitamin E isoform, and its natural or synthetic source, factors such as genetic polymorphisms and the clinical status of users also affect the impact of vitamin E supplementation on cardiovascular events. Conclusion: Patients with cardiovascular diseases, as well as those receiving preventive care for cardiovascular events or at risk of bleeding, should take Vitamin E only under medical supervision. Considering that low concentrations of antioxidants such as alpha-tocopherol can lead to greater susceptibility to diseases related to oxidative stress and inflammation in the population, reviewing or reinterpreting the mechanisms of vitamin E effects in the cardiovascular process is essential for a better understanding of the relationship between Vitamin E and cardiovascular diseases. It is equally important to establish public health initiatives and strategies to encourage the intake of natural vitamin E sources and healthy fats.