At-home autologous hematopoietic cell transplant for adults with hematological malignancies. How frailty impacts and evolves during HCT procedure. An observational, longitudinal, and prospective study

There was no association between the duration of at-home transplant hospitalisation and readmissions and the presence of frailty syndrome. Moreover, no patient died due to transplant-related toxicity. The results presented in this study support that at-home auto-HCT can be performed in fit, pre-frail, and frail adults with an experienced and multidisciplinary team. Although conclusions are limited by the reduced sample size, the observed differences on frailty incidences during patient's follow-up support that frailty is dynamic, and potentially amendable with specific interventions.

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Publication Details

Journal
Cancer Treatment and Research Communications
Published
2025-01-01
DOI
https://doi.org/10.1016/j.ctarc.2025.100920
Citations
1
Primary Topic
Frailty in Older Adults
Type
article
Field-Weighted Citation Impact
1.22
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article

At-home autologous hematopoietic cell transplant for adults with hematological malignancies. How frailty impacts and evolves during HCT procedure. An observational, longitudinal, and prospective study

Miquel Lozano, Beatriz Merchán, Alexandra Martínez‐Roca, Joan Cid et al.
1 citations
Cancer Treatment and Research Communications
Frailty in Older Adults
1.22
article

At-home autologous hematopoietic cell transplant for adults with hematological malignancies. How frailty impacts and evolves during HCT procedure. An observational, longitudinal, and prospective study

Miquel Lozano, Beatriz Merchán, Alexandra Martínez‐Roca, Joan Cid, María Queralt Salas, Noemí Llobet, Enric Carreras, Nuria Ballestar, Sara Laxe, Juan Ortiz, Laia Guardia, Paola Charry, María Teresa Solano, María Suárez‐Lledó, Cristina Gallego, Laura Rosiñol, Montserrat Rovira, Carmen Martínez, Francesc Fernández-Avilés, Raquel Salinas, Concepción Closa
article en
1 citations

Abstract

There was no association between the duration of at-home transplant hospitalisation and readmissions and the presence of frailty syndrome. Moreover, no patient died due to transplant-related toxicity. The results presented in this study support that at-home auto-HCT can be performed in fit, pre-frail, and frail adults with an experienced and multidisciplinary team. Although conclusions are limited by the reduced sample size, the observed differences on frailty incidences during patient's follow-up support that frailty is dynamic, and potentially amendable with specific interventions.

Cancer Treatment and Research CommunicationsVol. 43
Hospital Clínic de Barcelona (ES), Hospital de Galdakao (ES), Fundación Josep Carreras Contra la Leucemia (ES), Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES), Universitat de Barcelona (ES)
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Openalex Percentile: Top 25%
Frailty in Older Adults
1.22
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