A Bioinert Hydrogel Framework for Precision 3D Cell Cultures: Advancing Automated High‐Content and High‐Throughput Drug Screening

Drug Screening In article number 2400440, Yichun Wang and co-workers present a scalable, cost-effective method for high-throughput drug testing using 3D cell culture models. A bioinert hydrogel-based inverted colloidal crystal (BhiCC) framework enables uniform cultivation of over 1,000 spheroids per well. The approach enhances drug response reliability and supports automated analysis, advancing tissue engineering, disease modeling, and drug discovery applications.