EXPLORING THE ROLE OF LONG NON-CODING RNAs AS BIOMARKERS IN CARDIOVASCULARDISEASE: A BIBLIOMETRIC ANALYSIS

Background: Cardiovascular diseases (CVDs) are a leading cause of mortality globally, necessitating novel biomarkers for diagnosis and treatment. Long non-coding RNAs (lncRNAs) have emerged as significant regulatory molecules in cardiovascular biology, yet comprehensive bibliometric analyses in this area are lacking. Objective: This study aims to conduct a bibliometric analysis of lncRNAs as biomarkers in CVD to identify publication trends, key contributors, and thematic developments from 2008 to 2023. Methods: A systematic search was performed across PubMed, Scopus, and Web of Science using the keywords "((Long non-coding RNA) OR (lncRNA)) AND (Cardiovascular disease) OR (Cardiovascular disorders) AND (Biomarkers)." A total of 33,805 records were retrieved, with duplicates removed, resulting in 29,545 unique records. After screening, 341 relevant articles were selected for bibliometric analysis using VOSviewer. Results: A total of 341 publications were analyzed, involving 54 countries/regions, 548 institutions, and 1744 authors across 177 journals. The United States (84 publications) and China (61 publications) were the leading contributors. Zhengzhou University had the highest publication output, while Guo Wei was the most prolific author. Keyword analysis revealed a focus on lncRNAs' roles in the occurrence, development, diagnosis, treatment, and prognosis of CVD. Conclusion: This bibliometric analysis provides insights into the research landscape of lncRNAs as biomarkers in CVD, highlighting significant trends, influential authors, and collaborative networks. The findings underscore the importance of lncRNAs in cardiovascular research and suggest potential areas for future investigation