Polygenic dissection of treatment-resistant depression with proxy phenotypes in the UK Biobank
Our findings support a significant polygenic basis for TRD, highlighting genetic and phenotypic distinctions from non-TRD. We demonstrate that different TRD<sub>p</sub> endpoints are enriched with various spectra of psychiatric genetic liability, offering insights into pharmacogenomics and TRD's complex genetic architecture.
Authors
- Yen‐Chen Anne Feng (ORCID: https://orcid.org/0000-0003-2116-3645)
- Po‐Hsiu Kuo (ORCID: https://orcid.org/0000-0003-0365-3587)
- Mei-Chiung Shih
- Ling-Hua Wang
- Kuang Lin (ORCID: https://orcid.org/0000-0003-3017-6026)
Institutions
- National Yang Ming Chiao Tung University (TW)
- National Health Research Institutes (TW)
- National Taiwan University (TW)
- National Taipei University of Nursing and Health Science (TW)
- National Taiwan University Hospital (TW)
Publication Details
- Journal
- Journal of Affective Disorders
- Published
- 2025-04-06
- DOI
- https://doi.org/10.1016/j.jad.2025.04.012
- Citations
- 3
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 5.45
Funders
- Ministry of Education
- National Science and Technology Council