Unravelling soluble (pro)renin receptor-mediated endothelial dysfunction
Elevated s(P)RR induces endothelial dysfunction at least partially through AT<sub>1</sub>R. PRO20 prevents s(P)RR-AT<sub>1</sub>R formation, suggesting it could be an effective therapeutic for preeclampsia and conditions requiring renin-angiotensin system suppression.
Authors
- Kirsty G. Pringle (ORCID: https://orcid.org/0000-0002-6770-0496)
- Eugenie R. Lumbers (ORCID: https://orcid.org/0000-0003-3945-3923)
- Saije K. Endacott (ORCID: https://orcid.org/0000-0001-8974-5575)
- Sarah J. Delforce (ORCID: https://orcid.org/0000-0003-3109-1518)
- Lachlan G. Schofield (ORCID: https://orcid.org/0009-0008-9980-4338)
- Dan Ma (ORCID: https://orcid.org/0000-0003-0593-397X)
- Yu Wang (ORCID: https://orcid.org/0000-0002-9703-8827)
- Juyi Zhao
Institutions
- Berry College (US)
- Hunter Medical Research Institute (AU)
- Hebei University (CN)
- University of Newcastle Australia (AU)
Publication Details
- Journal
- European Journal of Pharmacology
- Published
- 2025-04-05
- DOI
- https://doi.org/10.1016/j.ejphar.2025.177601
- Citations
- 4
- Primary Topic
- Renin-Angiotensin System Studies
- Type
- article
- Field-Weighted Citation Impact
- 5.55
Funders
- Hebei Normal University of Science and Technology
- Innovative Research Group Project of the National Natural Science Foundation of China
- National Natural Science Foundation of China
- Hebei University
- National Health and Medical Research Council