The Role of Antidiabetic Drugs in Bone Health: Assessing the Risk of Osteoporosis Subtypes and Fractures Using Mendelian Randomization

The results highlight the potential bone-protective role of Metformin, which may be suitable for patients at high fracture risk. On the other hand, the use of GLP-1 receptor agonists and Gliclazide should be carefully considered, especially in individuals with osteoporosis or at high risk of fractures. These findings emphasize the importance of personalized medication management in diabetic patients to optimize bone health.

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Publication Details

Journal
Orthopedic Research and Reviews
Published
2025-04-01
DOI
https://doi.org/10.2147/orr.s508278
Citations
4
Primary Topic
Genetic factors in colorectal cancer
Type
article
Field-Weighted Citation Impact
5.89
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article

The Role of Antidiabetic Drugs in Bone Health: Assessing the Risk of Osteoporosis Subtypes and Fractures Using Mendelian Randomization

Liping Wu, Junxin Zhou, Gaorong Deng, 水谷 武雄 et al.
4 citations
Orthopedic Research and Reviews
Genetic factors in colorectal cancer
5.89
article

The Role of Antidiabetic Drugs in Bone Health: Assessing the Risk of Osteoporosis Subtypes and Fractures Using Mendelian Randomization

Liping Wu, Junxin Zhou, Gaorong Deng, 水谷 武雄, Zongfang Li
article en
4 citations

Abstract

The results highlight the potential bone-protective role of Metformin, which may be suitable for patients at high fracture risk. On the other hand, the use of GLP-1 receptor agonists and Gliclazide should be carefully considered, especially in individuals with osteoporosis or at high risk of fractures. These findings emphasize the importance of personalized medication management in diabetic patients to optimize bone health.

Orthopedic Research and ReviewsVol. Volume 17
Nanchang University (CN), Jiangxi Science and Technology Normal University (CN), Jiangxi Provincial People's Hospital (CN), Second Affiliated Hospital of Nanchang University (CN), Second Affiliated Hospital of Xi'an Jiaotong University (CN), First Affiliated Hospital of Nanchang University (CN)
Good health and well-being
Openalex Percentile: Top 4%
Genetic factors in colorectal cancer
5.89
DOIOpen Access PDFOpenAlex
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The Role of Antidiabetic Drugs in Bone Health: Assessing the Risk of Osteoporosis Subtypes and Fractures Using Mendelian Randomization — Liping Wu, Junxin Zhou, et al. · Orthopedic Research and Reviews (2025) | TGRS Research Map | TGRS