NAD+ boosting increases atherosclerotic plaques and inflammation in Apoe knockout mice
High-dose NR supplementation in mice did not decrease but increase both aortic plaque lesions and systemic inflammation. These effects may be mediated by increased CD38 expression in macrophages, with NAD<sup>+</sup> metabolism shifted from sirtuins towards CD38 and PARP1 pathways. Caution should be applied with presumed NAD<sup>+</sup> boosters in patients with atherosclerosis.
Authors
- Sokrates Stein (ORCID: https://orcid.org/0000-0001-6984-6934)
- Johan Auwerx (ORCID: https://orcid.org/0000-0002-5065-5393)
- Jürgen Pahla
- Era Gorica (ORCID: https://orcid.org/0000-0003-1743-2013)
- Stephan Winnik
- Frank Thomas Ruschitzka (ORCID: https://orcid.org/0000-0001-5972-0596)
- Karim Gariani (ORCID: https://orcid.org/0000-0001-8089-4785)
- Sarah Costantino (ORCID: https://orcid.org/0000-0002-3003-7213)
- Zeneng Wang (ORCID: https://orcid.org/0000-0002-6455-8228)
- Elena Osto (ORCID: https://orcid.org/0000-0001-8196-5696)
- Christian M. Matter (ORCID: https://orcid.org/0000-0002-8124-1767)
- Stanley L. Hazen (ORCID: https://orcid.org/0000-0001-7124-6639)
- Tina Dahlby (ORCID: https://orcid.org/0000-0003-1656-0814)
- Daniel S. Gaul
- Yu-Jen Wang (ORCID: https://orcid.org/0000-0001-8387-3947)
- S A Mohammed (ORCID: https://orcid.org/0000-0003-2365-5037)
- E Dietrich (ORCID: https://orcid.org/0009-0005-2938-775X)
Institutions
- Cleveland Clinic (US)
- University of Zurich (CH)
- ETH Zurich (CH)
- Cleveland Clinic Lerner College of Medicine (US)
- University Hospital of Zurich (CH)
- University Hospital of Geneva (CH)
- École Polytechnique Fédérale de Lausanne (CH)
Publication Details
- Journal
- Atherosclerosis
- Published
- 2025-04-05
- DOI
- https://doi.org/10.1016/j.atherosclerosis.2025.119188
- Citations
- 3
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 3.67
Funders
- Foundation for the National Institutes of Health
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Schweizerische Herzstiftung
- Universität Zürich
- Universitätsspital Zürich
- National Institutes of Health