Investigation of PDE5 effect on NOS in nasal polyp pathophysiology
The mean age was 47.40 ± 16.33 years in the nasal polyp group and 35.44 ± 12.47 years in the normal group, and 64.0% (n = 16) of both groups were male. ELISA measurements showed that PDE5 levels were significantly decreased and iNOS and eNOS levels were significantly increased in the nasal polyp group compared with the control group. CONCLUSıON: This study suggest that iNOS, eNOS, and PDE5 may play important roles in the pathophysiology of nasal polyps.
Authors
- Zekai Halıcı (ORCID: https://orcid.org/0000-0001-6854-6059)
- Ayşegül Tavacı Özçelik
- Vahit Mutlu (ORCID: https://orcid.org/0000-0002-2803-3328)
- Zülküf Kaya (ORCID: https://orcid.org/0000-0002-9378-1672)
- Abdullah Serdar Topatan (ORCID: https://orcid.org/0009-0004-4683-0648)
Institutions
- Atatürk University (TR)
Publication Details
- Journal
- European Archives of Oto-Rhino-Laryngology
- Published
- 2025-04-05
- DOI
- https://doi.org/10.1007/s00405-025-09362-4
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Türkiye Bilimsel ve Teknolojik Araştırma Kurumu
- Atatürk Üniversitesi