The Role of von Willebrand Factor in the Pathogenesis of C3 Glomerulopathy
The levels of vWF were associated with disease severity and poor prognosis of patients with C3G. <i>VWF</i> gene deficiency led to the aggravation of kidney damage and FH overexpression in C3G mouse model, which indicated that vWF might play a protective role in the pathogenesis of C3G.
Authors
- Ying Tan (ORCID: https://orcid.org/0000-0002-8139-5758)
- Ming‐Hui Zhao (ORCID: https://orcid.org/0000-0003-3340-3108)
- Yunying Chen
- Feng Yu (ORCID: https://orcid.org/0000-0003-3060-6233)
- Shasha Han
- Min Chen (ORCID: https://orcid.org/0000-0002-9292-0861)
- Xiaojuan Yu (ORCID: https://orcid.org/0000-0002-6017-7188)
- Zixin Hua
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Beijing Hospital (CN)
- Peking University International Hospital (CN)
Publication Details
- Journal
- Kidney International Reports
- Published
- 2025-04-05
- DOI
- https://doi.org/10.1016/j.ekir.2025.03.058
- Primary Topic
- Complement system in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00