Multi-omics insights into the roles of CCNB1, PLK1, and HPSE in breast cancer progression: implications for prognosis and immunotherapy
This study provides evidence that CCNB1, PLK1, and HPSE are key players in breast cancer progression and potential biomarkers for prognosis. Furthermore, their roles in immune regulation suggest they could be promising targets for immunotherapy.
Authors
- Huiqiang Zhang (ORCID: https://orcid.org/0000-0003-3369-075X)
- Zhimin Yun
- Zhangrong Lou (ORCID: https://orcid.org/0009-0006-9352-6002)
- Qisheng Su (ORCID: https://orcid.org/0000-0003-3858-1018)
- Ruilin Ma (ORCID: https://orcid.org/0000-0002-1444-1670)
- He Liu (ORCID: https://orcid.org/0009-0004-9016-3512)
- Qi Liu (ORCID: https://orcid.org/0000-0002-5031-2964)
- Zhi Chen (ORCID: https://orcid.org/0000-0003-0529-5875)
- Chaofan Li (ORCID: https://orcid.org/0000-0002-3041-3004)
- Leiming Fang (ORCID: https://orcid.org/0000-0001-5256-579X)
- Ying-Xia Tan
- Liang Yu (ORCID: https://orcid.org/0009-0007-3922-3454)
- Xiaopeng Hao (ORCID: https://orcid.org/0000-0002-0736-8962)
- Pengfei Zhong (ORCID: https://orcid.org/0009-0001-6021-2625)
- Chengjun Wu (ORCID: https://orcid.org/0000-0001-9940-2605)
Institutions
- Guangxi Medical University (CN)
- Hebei North University (CN)
- Dalian University of Technology (CN)
- Chinese PLA General Hospital (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-04-05
- DOI
- https://doi.org/10.1007/s12672-025-02282-z
- Citations
- 2
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- National Natural Science Foundation of China