Vitamin D receptor: a possible biomarker for sporadic parathyroid adenoma?
Parathyroid adenoma is the main cause of primary hyperparathyroidism. The genetic basis of the disease is still unclear. Vitamin D receptor (VDR) is involved in parathormone regulation. The aim of this study is to evaluate Vitamin D receptor expression in sporadic parathyroid adenoma. Fifty-one patients with parathyroid adenoma and 51 healthy volunteers were enrolled in the study and genetic and immunohistochemical studies were conducted. VDR polymorphism TaqI was correlated with parathyroid adenoma development, while VDR stained positive in immunohistochemical study. Our study suggests VDR as a major contributor to sporadic parathyroid adenoma formation in Greek population.
Authors
- Anthoula Chatzikyriakidou (ORCID: https://orcid.org/0000-0002-4194-4222)
- Angeliki Chorti (ORCID: https://orcid.org/0000-0003-1028-4476)
- Papavramidis Theodossis
- Charoula Achilla (ORCID: https://orcid.org/0000-0001-9015-8597)
- Sohail Bakkar (ORCID: https://orcid.org/0000-0001-8479-5901)
- Despoina Tsalkatidou
- Despoina Krokou
- Angeliki Cheva (ORCID: https://orcid.org/0000-0002-5374-1772)
- Kassiani Boulogeorgou (ORCID: https://orcid.org/0000-0001-7625-1680)
Institutions
- Hashemite University (JO)
- Aristotle University of Thessaloniki (GR)
- AHEPA University Hospital (GR)
- Kyanous Stavros Hospital (GR)
- Euromedica (GR)
Publication Details
- Journal
- Updates in Surgery
- Published
- 2025-04-05
- DOI
- https://doi.org/10.1007/s13304-025-02182-5
- Citations
- 2
- Primary Topic
- Parathyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.86
Funders
- Aristotle University of Thessaloniki