Glucose absorption by isolated, vascularly perfused rat intestine: A significant paracellular contribution augmented by <scp>SGLT1</scp> inhibition
In this model, glucose absorption occurs via both active transcellular and passive paracellular transport, particularly in the proximal intestine, which is important for the understanding of, for example, hormone secretion related to glucose absorption. Interference with SGLT1 activity may lead to enhanced paracellular transport, pointing to a role in the regulation of the latter.
Authors
- Rune E. Kuhre (ORCID: https://orcid.org/0000-0003-4787-340X)
- Ida Marie Modvig (ORCID: https://orcid.org/0000-0002-6824-2802)
- Cecilie Bæch‐Laursen (ORCID: https://orcid.org/0000-0002-8526-1079)
- Simon Veedfald (ORCID: https://orcid.org/0000-0002-0797-3417)
- Jens Juul Holst (ORCID: https://orcid.org/0000-0001-6853-3805)
Institutions
- University of Copenhagen (DK)
- Novo Nordisk (Denmark) (DK)
- Novo Nordisk Foundation (DK)
- Rigshospitalet (DK)
Publication Details
- Journal
- Acta Physiologica
- Published
- 2025-04-04
- DOI
- https://doi.org/10.1111/apha.70033
- Citations
- 2
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 2.59
Funders
- Novo Nordisk
- Novo Nordisk Fonden
- Novo Nordisk Foundation Center for Basic Metabolic Research