The toxicity of chlorhexidine and povidone-iodine to rotator cuff tendon
Brief 0.05% CHG and 0.35% PI exposures to rotator cuff tendon may lead to reduced tenocyte viability, with the tendinous portion seemingly more susceptible than the enthesis. Additionally, at these concentrations tested, CHG appears to be more toxic than PI. These findings raise concern for the potential cytotoxic effects of low-dose CHG and PI on native tendon tissue, even after brief exposures commonly used for antimicrobial prophylaxis in shoulder arthroplasty.
Authors
- Kyriacos A. Athanasiou (ORCID: https://orcid.org/0000-0001-5387-8405)
- Maziar Moslehyazdi
- Benjamin J. Bielajew (ORCID: https://orcid.org/0000-0003-0580-9864)
- Tyler Robert Johnston (ORCID: https://orcid.org/0000-0002-9262-0527)
- Kory B. Dylan Pasko (ORCID: https://orcid.org/0000-0001-8669-344X)
- Jerry C. Hu (ORCID: https://orcid.org/0000-0003-0651-1461)
- Dean Wang (ORCID: https://orcid.org/0000-0002-3005-1154)
Institutions
- Georgetown University (US)
- University of California, Irvine (US)
- Irvine University (US)
Publication Details
- Journal
- Journal of Shoulder and Elbow Surgery
- Published
- 2025-04-05
- DOI
- https://doi.org/10.1016/j.jse.2025.02.054
- Citations
- 1
- Primary Topic
- Shoulder Injury and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.01