Refining early detection of Marburg Virus Disease (MVD) in Rwanda: Leveraging predictive symptom clusters to enhance case definitions
Early symptom clusters, especially constitutional and gastrointestinal signs outperformed hemorrhagic symptoms for MVD detection. Findings challenge current case definitions, emphasizing the need for revised public health messaging and healthcare worker training. Integrating symptom-based models into surveillance could enhance detection, especially in resource-limited settings.
Authors
- Lyndah Makayotto
- Eric Remera (ORCID: https://orcid.org/0000-0002-6084-8877)
- Muhammed Semakula (ORCID: https://orcid.org/0000-0002-9076-4922)
- David Turatsinze
- Edson Rwagasore (ORCID: https://orcid.org/0009-0006-5002-0829)
- Claude Mambo Muvunyi (ORCID: https://orcid.org/0000-0003-4180-442X)
- Richard Muvunyi (ORCID: https://orcid.org/0009-0006-7594-8754)
- Faustin Ntirenganya (ORCID: https://orcid.org/0000-0001-8886-8100)
- Yvan Butera (ORCID: https://orcid.org/0000-0002-0648-2384)
- Pacifique Nizeyimana
- Ziad El‐Khatib
- Menelas Nkeshimana (ORCID: https://orcid.org/0000-0003-3573-8075)
- Aloysius Rukundo (ORCID: https://orcid.org/0000-0002-6518-4360)
- Sabin Nsanzimana (ORCID: https://orcid.org/0000-0002-5946-0015)
- Olivier Nsekuye (ORCID: https://orcid.org/0000-0002-9238-4691)
- Brian Chirombo (ORCID: https://orcid.org/0000-0002-9953-6061)
- Frederick Ntabana
- Hugues Valois Mucunguzi (ORCID: https://orcid.org/0009-0009-4054-3417)
Institutions
- World Health Organization - Pakistan (PK)
- Karolinska Institutet (SE)
- Adventist University of Central Africa (RW)
- Rwanda Development Board (RW)
- Centre Hospitalier Universitaire de Kigali (RW)
- Rwanda Biomedical Center (RW)
- Ministry of Health (RW)
Publication Details
- Journal
- International Journal of Infectious Diseases
- Published
- 2025-04-05
- DOI
- https://doi.org/10.1016/j.ijid.2025.107902
- Citations
- 6
- Primary Topic
- Viral Infections and Outbreaks Research
- Type
- article
- Field-Weighted Citation Impact
- 8.38