Prioritizing endocrine-disrupting chemicals targeting systemic lupus erythematosus genes via Mendelian randomization and colocalization analyses
This study highlights the complex interactions between EDCs and genetic predisposition in SLE. The findings provide valuable insights into how environmental exposures, particularly EDCs, may contribute to the development and progression of autoimmune diseases like SLE. These results suggest potential targets for future therapeutic interventions and underscore the need for further research on gene-environment interactions in SLE.
Authors
- Sheng Gao (ORCID: https://orcid.org/0000-0002-8622-5694)
- Chunyan Hua (ORCID: https://orcid.org/0000-0001-7957-6106)
- Qianru Yang (ORCID: https://orcid.org/0009-0007-2812-7678)
- Rujie Chen
- Yi Wang (ORCID: https://orcid.org/0000-0002-8391-1453)
- Yanggang Hong (ORCID: https://orcid.org/0009-0004-4507-0093)
- Deqi Wang
- Wanyi Shu
- Xiaoyang Jiang (ORCID: https://orcid.org/0009-0008-8368-5637)
- Chenchen Shao
Institutions
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
Publication Details
- Journal
- Ecotoxicology and Environmental Safety
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1016/j.ecoenv.2025.118126
- Citations
- 10
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 16.68
Funders
- Zhejiang University Student Science and Technology Innovation Activity Plan
- Science and Technology Plan Project of Wenzhou, China
- Natural Science Foundation of Zhejiang Province