IN VITRO ANTIOXIDANT AND ANTIRADICAL ACTIVITY OF THE TOTAL POLYPHENOLS (SUBSTANCES OF THE ANTIVIRAL DRUG RUTAN) OF THE LEAVES OF TANNIC SUMACH RHUS CORIARIA L.

As a result of the study of antiradical and antioxidant activities under in vitro conditions, it was determined that Rutan has a high antiradical activity to the free radical DPPH, it is a verified antioxidant, the mechanism of action of which is the release of transportable hydrogen to the free radical, resulting in the chain termination of the peroxidation reaction lipids (LPO). This fact is also confirmed by the correlation coefficient r=0.94 between the manifestation of antioxidant and antiradical properties. In experiments on the ability to inhibit the opening of mPTP, it was shown that Rutan has a protective effect on mitochondrion, depending on the concentration, reducing the damaging effect of Ca2+ ions on the process of mPTP opening and is an effective regulator and modifier of the CsA-sensitive mitochondrion pore. Additionally, Rutan affects the activity of the ATP-dependent potassium channel and the enzyme-cardiomarker – creatine kinase, thereby possessing a cardioprotective mechanism and preserving the vital activity of myocardial cells.